研究業績

学術論文

2025年

• "Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring"
  Nunobiki S, Yoshimoto A, Ito M, Yonoichi S, Hara Y, Ishida Y, Morishita R, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  J Vet Med Sci 87, 4, 411-418 (2025).
• "Effects of low-dose subchronic exposure to the phenylpyrazole insecticide fipronil in juvenile mice"
  Yoshimoto A, Nunobiki S, Ito M, Yonoichi S, Hara Y, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  J Vet Med Sci 87, 4, 419-425 (2025).

2024年

• "Effects of exposure to the neonicotinoid pesticide clothianidin on mouse intestinal microbiota under unpredictable environmental stress."
  Yonoichi S, Hirano T, Hara Y, Ishida Y, Shoda A, Kimura M, Murata M, Mantani Y, Yokoyama T, Ikenaka Y, Hoshi N.
  Toxicol Appl Pharmacol. 482, 116795 (2024).
• "Genes involved in osteogenic differentiation induced by low_intensity pulsed ultrasound in goldfish scales"
  Tabuchi Y, Kuroda K, Furusawa Y, Hirano T, Nagaoka R, Omura M, Hasegawa H, Hirayama J, Suzuki N
  Biomed Rep 22, 2, 18 (2024).
• "Hydroxylated-Benz[a]anthracenes Induce Two Apoptosis-Related Gene Expressions in the Liver of the Nibbler Fish Girella punctata"
  Rafiuddin MA, Matsubara H, Hatano K, Honda M, Toyota K, Kuroda K, Tsunoda K, Furusawa Y, Tabuchi Y, Hirano T, Sakatoku A, Hong CS, Srivastav AK, Amornsakun T, Shimizu N, Zanaty MI, Harumi T, Yamauchi K, M_ller T, Tang N, Hattori A, Hayakawa K, Suzuki N
  Toxics 12, 915 (2024).
• "Genes involved in osteogenic differentiation induced by low_intensity pulsed ultrasound in goldfish scales"
  Tabuchi Y, Kuroda K, Furusawa Y, Hirano T, Nagaoka R, Omura M, Hasegawa H, Hirayama J, Suzuki N
  Biomed Rep 22, 18 (2024).
• "Effects of exposure to the neonicotinoid pesticide clothianidin on mouse intestinal microbiota under unpredictable environmental stress"
  Yonoichi S, Hirano T（＊責任著者）, Hara Y, Ishida Y, Shoda A, Kimura M, Murata M, Mantani Y, Yokoyama T, Ikenaka Y, Hoshi N
  Toxicol Appl Pharmacol 482, 116795 (2024).
• "Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice"
  Yonoichi S, Hara Y, Ishida Y, Shoda A, Kimura M, Murata M, Nunobiki S, Ito M, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Yokoi Y, Ayabe T, Nakamura K, Hoshi N＊
  J Vet Med Sci 86, 3, 277-284 (2024).
• "Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis"
  Ishida Y, Yonoichi S, Hara Y, Shoda A, Kimura M, Murata M, Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Matsuo E, Ikenaka Y, Hoshi N＊
  J Vet Med Sci 86, 3, 333-339 (2024).
• "Quantification of the tissue distribution and accumulation of the neonicotinoid pesticide clothianidin and its metabolites in maternal and fetal mice"
  Hirano T（＊責任著者）, Ohno S, Ikenaka Y, Onaru K, Kubo S, Miyata Y, Maeda M, Mantani Y, Yokoyama T, Nimako C, Yohannes YB, Nakayama SMM, Ishizuka M, Hoshi N
  Toxicol Appl Pharmacol 484, 116847 (2024).
• "Role of brain monoamines in acetamiprid-induced anxiety-like behavior"
  Hirai A, Toda C, Yohannes YB, Collins N, Tamba M, Nomiyama K, Eguchi A, Hoshi N, Hirano T, Nakayama SMM, Ishizuka M, Ikenaka Y＊
  Toxicology 505, 153839 (2024).
• "No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum"
  Hara Y, Shoda A, Yonoichi S, Ishida Y, Murata M, Kimura M, Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 86, 3, 340-348 (2024).

2023年

• "Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice"
  Shoda A, Nishi M, Murata M, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N＊
  Toxicol Lett 373, 33-40 (2023).
• "Developmental stage-specific exposure and neurotoxicity evaluation of low-dose clothianidin during neuronal circuit formation"
  Shoda A, Murata M, Kimura M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 85, 4, 486-496 (2023).
• "Transgenerational effects of developmental neurotoxicity induced by exposure to a no-observed-adverse-effect level (NOAEL) of neonicotinoid pesticide clothianidin"
  Shoda A, Murata M, Kimura M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N＊
  J Vet Med Sci 85, 9, 1023-1029 (2023).
• "Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota"
  Murata M, Shoda A, Kimura M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Matsuo E, Hirano T, Hoshi N＊
  J Vet Med Sci 85, 4, 434-442 (2023).
• "Neurotoxicity and behavioral disorders induced in mice by acute exposure to the diamide insecticide chlorantraniliprole"
  Kimura M, Shoda A, Murata M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N＊
  J Vet Med Sci 85, 4, 497-506 (2023).
• "An adverse outcome pathway-based approach to assess the neurotoxicity by combined exposure to current-use pesticides"
  Hirano T（＊責任著者）, Ikenaka Y, Nomiyama K, Honda M, Suzuki N, Hoshi N, Tabuchi Y
  Toxicology 500, 153687 (2023).

2022年

• "Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy in vivo imaging"
  Nishi M, Sugio S, Hirano T, Kato D, Wake H, Shoda A, Murata M, Ikenaka Y, Tabuchi Y, Mantani Y, Yokoyama T, Hoshi N＊
  J Vet Med Sci 84, 4, 585-592 (2022).
• "Sex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice"
  Kubo S, Hirano T（＊責任著者）, Miyata Y, Ohno S, Onaru K, Ikenaka Y, Nakayama SMM, Ishizuka M, Mantani Y, Yokoyama T, Hoshi N
  Toxicol Appl Pharmacol 456, 116283 (2022).
• "Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides"
  Hirai A, Sugio S, Nimako C, Nakayama SMM, Kato K, Takahashi K, Arizono K, Hirano T, Hoshi N, Fujioka K, Taira K, Ishizuka M, Wake H, Ikenaka Y＊
  Sci Rep 12, 1, 5114 (2022).

2021年

• "Genetic response to low_intensity ultrasound on mouse ST2 bone marrow stromal cells"
  Tabuchi Y＊, Hasegawa H, Suzuki N, Furusawa Y, Hirano T, Nagaoka R, Hirayama J, Hoshi N, Mochizuki T
  Mol Med Rep 23, 3 (2021).
• "The effects of fipronil on emotional and cognitive behaviors in mammals"
  Suzuki T, Hirai A, Khidkhan K, Nimako C, Ichise T, Takeda K, Mizukawa H, Nakayama SMM, Nomiyama K, Hoshi N, Maeda M, Hirano T, Sasaoka K, Sasaki N, Takiguchi M, Ishizuka M, Ikenaka Y＊
  Pestic Biochem Physiol 175, 104847 (2021).
• "Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice"
  Nimako C, Ikenaka Y, Okamatsu-Ogura Y, Bariuan JV, Kobayashi A, Yamazaki R, Taira K, Hoshi N, Hirano T, Nakayama SMM, Ishizuka M＊
  J Vet Med Sci 83, 3, 487-500 (2021).
• "Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice"
  Maeda M, Yokoyama T, Kitauchi S, Hirano T, Mantani Y, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 83, 2, 344-348 (2021).
• "Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice"
  Maeda M, Kitauchi S, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Yokoyama T, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 83, 3, 542-548 (2021).
• "Effects of in utero and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice"
  Kitauchi S, Maeda M, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Yokoyama T, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 83, 4, 746-753 (2021).
• "Bioinformatics analysis of the microRNA-mRNA network in sebaceous gland carcinoma of the eyelid"
  Hirano T, Yunoki T, Furusawa Y, Tabuchi Y＊, Hayashi A
  Mol Med Rep 23, 1 (2021).
• "Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition"
  Hirano T（＊責任著者）, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y
  Toxicol Appl Pharmacol 430, 115723 (2021).
• "Aging-related changes in the sensitivity of behavioral effects of the neonicotinoid pesticide clothianidin in male mice"
  Hirano T（＊責任著者）, Miyata Y, Kubo S, Ohno S, Onaru K, Maeda M, Kitauchi S, Nishi M, Tabuchi Y, Ikenaka Y, Ichise T, Nakayama SMM, Ishizuka M, Arizono K, Takahashi K, Kato K, Mantani Y, Yokoyama T, Hoshi N
  Toxicol Lett 342, 95-103 (2021).

2020年

• "CDKN2A, CDK1, and CCNE1 overexpression in sebaceous gland carcinoma of eyelid"
  Yunoki T＊, Hirano T, Tabuchi Y, Furusawa Y, Torigoe M, Nakajima T, Imura J, Hayashi A
  Int Ophthalmol 40, 2, 343-350 (2020).
• "Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice"
  Takada T, Yoneda N, Hirano T, Onaru K, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Nimako C, Ishizuka M, Ikenaka Y, Hoshi N＊
  J Vet Med Sci 82, 3, 350-359 (2020).
• "HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC_3 cells"
  Tabuchi Y＊, Maekawa K, Torigoe M, Furusawa Y, Hirano T, Minagawa S, Yunoki T, Hayashi A
  Int J Mol Med 46, 1, 58-66 (2020).
• "Low-intensity pulsed ultrasound promotes the expression of immediate-early genes in mouse ST2 bone marrow stromal cells"
  Tabuchi Y＊, Hasegawa H, Suzuki N, Furusawa Y, Hirano T, Nagaoka R, Takeuchi SI, Shiiba M, Mochizuki T
  J Med Ultrason 47, 2, 193-201 (2020).
• "Immunotoxicity evaluation by subchronic oral administration of clothianidin in Sprague-Dawley rats"
  Onaru K, Ohno S, Kubo S, Nakanishi S, Hirano T, Mantani Y, Yokoyama T, Hoshi N＊
  J Vet Med Sci 82, 3, 360-372 (2020).
• "Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice"
  Ohno S, Ikenaka Y, Onaru K, Kubo S, Sakata N, Hirano T, Mantani Y, Yokoyama T, Takahashi K, Kato K, Arizono K, Ichise T, Nakayama SMM, Ishizuka M, Hoshi N＊
  Toxicol Lett 322, 32-38 (2020).
• "Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads"
  Hasegawa C, Yokoyama T＊, Umemura Y, Kawanishi K, Miura Y, Takada N, Ohno S, Onaru K, Omotehara T, Hirano T, Mantani Y, Miki T, Hoshi N
  J Vet Med Sci 82, 4, 414-421 (2020).

2019年

• "Genetic differences between C57BL/6 substrains affect the process of testis differentiation in YPOS mice"
  Yokoyama T＊, Miura Y, Yamamoto A, Hasegawa C, Kawanishi K, Takada N, Omotehara T, Hirano T, Mantani Y, Miki T, Hoshi N
  J Vet Med Sci 81, 4, 608-611 (2019).
• "Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells"
  Hirano T（＊責任著者）, Minagawa S, Furusawa Y, Yunoki T, Ikenaka Y, Yokoyama T, Hoshi N, Tabuchi Y
  Toxicol Appl Pharmacol 383, 114777 (2019).

2018年

• "Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling"
  Yunoki T＊, Tabuchi Y, Hirano T, Miwa S, Imura J, Hayashi A
  Oncol Lett 16, 5, 6729-6734 (2018).
• "Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice"
  Yoneda N, Takada T, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 80, 4, 634-637 (2018).
• "Identification of reference genes for quantitative PCR analyses in developing mouse gonads"
  Yokoyama T＊, Omotehara T, Hirano T, Kubota N, Yanai S, Hasegawa C, Takada T, Mantani Y, Hoshi N
  J Vet Med Sci 80, 10, 1534-1539 (2018).
• "The mechanisms underlying the effects of AMH on M_llerian duct regression in male mice"
  Yamamoto A, Omotehara T, Miura Y, Takada T, Yoneda N, Hirano T, Mantani Y, Kitagawa H, Yokoyama T, Hoshi N＊
  J Vet Med Sci 80, 4, 557-567 (2018).
• "Verification of the causal relationship between subchronic exposures to dinotefuran and depression-related phenotype in juvenile mice"
  Takada T, Yoneda N, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 80, 4, 720-724 (2018).
• "NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with human-audible vocalizations in male mice in a novel environment"
  Hirano T, Yanai S, Takada T, Yoneda N, Omotehara T, Kubota N, Minami K, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  Toxicol Lett 282, 57-63 (2018).
• "Identification of genes and genetic networks associated with BAG3_dependent cell proliferation and cell survival in human cervical cancer HeLa cells"
  Furusawa Y＊, Yunoki T, Hirano T, Minagawa S, Izumi H, Mori H, Hayashi A, Tabuchi Y
  Mol Med Rep 18, 4, 4138-4146 (2018).

2017年

• "Prenatal and early postnatal NOAEL-dose clothianidin exposure leads to a reduction of germ cells in juvenile male mice"
  Yanai S, Hirano T, Omotehara T, Takada T, Yoneda N, Kubota N, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 79, 7, 1196-1203 (2017).
• "Contribution of the coelomic epithelial cells specific to the left testis in the chicken embryo"
  Omotehara T, Minami K, Mantani Y, Umemura Y, Nishida M, Hirano T, Yoshioka H, Kitagawa H, Yokoyama T, Hoshi N＊
  Dev Dyn 246, 2, 148-156 (2017).

2016年

• "Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XYPOS mice"
  Umemura Y, Miyamoto R, Hashimoto R, Kinoshita K, Omotehara T, Nagahara D, Hirano T, Kubota N, Minami K, Yanai S, Masuda N, Yuasa H, Mantani Y, Matsuo E, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 77, 12, 1587-1598 (2016).

2015年

• "Immunohistochemical analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity on the developmental dentate gyrus and hippocampal fimbria in fetal mice"
  Kobayashi Y, Hirano T, Omotehara T, Hashimoto R, Umemura Y, Yuasa H, Masuda N, Kubota N, Minami K, Yanai S, Ishihara-Sugano M, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 77, 11, 1355-1361 (2015).
• "The combined effect of clothianidin and environmental stress on the behavioral and reproductive function in male mice"
  Hirano T, Yanai S, Omotehara T, Hashimoto R, Umemura Y, Kubota N, Minami K, Nagahara D, Matsuo E, Aihara Y, Shinohara R, Furuyashiki T, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 77, 10, 1207-1215 (2015).

2014年

• "Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing gonads and Mullerian ducts"
  Omotehara T, Smith CA, Mantani Y, Kobayashi Y, Tatsumi A, Nagahara D, Hashimoto R, Hirano T, Umemura Y, Yokoyama T, Kitagawa H, Hoshi N＊
  Poult Sci 93, 4, 953-958 (2014).
• "Insight into the mechanism of reproductive dysfunction caused by neonicotinoid pesticides"
  Hoshi N＊, Hirano T, Omotehara T, Tokumoto J, Umemura Y, Mantani Y, Tanida T, Warita K, Tabuchi Y, Yokoyama T, Kitagawa H
  Biol Pharm Bull 37, 9, 1439-1443 (2014).
• "Unpredictable chronic stress-induced reproductive suppression associated with the decrease of kisspeptin immunoreactivity in male mice"
  Hirano T, Kobayashi Y, Omotehara T, Tatsumi A, Hashimoto R, Umemura Y, Nagahara D, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 76, 9, 1201-1208 (2014).