研究業績

2025年

学術論文

• "Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring"
  Nunobiki S, Yoshimoto A, Ito M, Yonoichi S, Hara Y, Ishida Y, Morishita R, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  J Vet Med Sci 87, 4, 411-418 (2025).
• "Effects of low-dose subchronic exposure to the phenylpyrazole insecticide fipronil in juvenile mice"
  Yoshimoto A, Nunobiki S, Ito M, Yonoichi S, Hara Y, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  J Vet Med Sci 87, 4, 419-425 (2025).

学会発表

• "化学物質が高次脳機能に及ぼす未知の影響とシグナル毒性評価に向けた新展開"
  平野哲史
  第4回環境化学物質合同大会．特別企画２「シグナル毒性と神経攪乱の評価に向けた革新技術」 (2025).
• "化学物質が高次脳機能に及ぼす未知の影響とシグナル毒性評価に向けた新展開"
  平野哲史
  第4回環境化学物質合同大会；2025 Jul 15-18；山形 (2025).

  招待講演
• "農神経毒性AOPの共通Key Eventに基づいた農薬類の複合影響評価法の開発"
  平野哲史
  日本衛生学会若手研究者夏の集い2025；2025 Aug 4；伊勢原 (2025).
• "化学物質の複合影響評価に向けた神経毒性の共通Key eventを指標とするin vitroアッセイ系の構築"
  平野哲史，池中良徳，星　信彦，田渕圭章
  第52回日本毒性学会学術年会；2025 Jul 2-4；沖縄 (2025).
• "農薬類によるグリア－ニューロン間相互作用の撹乱を介した新たな神経毒性機序の解明"
  平野哲史，池中良徳，星　信彦，田渕圭章
  第95回日本衛生学会学術集会；2025 Mar 19-21；大宮 (2025).

2024年

学術論文

• "Effects of exposure to the neonicotinoid pesticide clothianidin on mouse intestinal microbiota under unpredictable environmental stress."
  Yonoichi S, Hirano T, Hara Y, Ishida Y, Shoda A, Kimura M, Murata M, Mantani Y, Yokoyama T, Ikenaka Y, Hoshi N.
  Toxicol Appl Pharmacol. 482, 116795 (2024).
• "Genes involved in osteogenic differentiation induced by low_intensity pulsed ultrasound in goldfish scales"
  Tabuchi Y, Kuroda K, Furusawa Y, Hirano T, Nagaoka R, Omura M, Hasegawa H, Hirayama J, Suzuki N
  Biomed Rep 22, 2, 18 (2024).
• "Hydroxylated-Benz[a]anthracenes Induce Two Apoptosis-Related Gene Expressions in the Liver of the Nibbler Fish Girella punctata"
  Rafiuddin MA, Matsubara H, Hatano K, Honda M, Toyota K, Kuroda K, Tsunoda K, Furusawa Y, Tabuchi Y, Hirano T, Sakatoku A, Hong CS, Srivastav AK, Amornsakun T, Shimizu N, Zanaty MI, Harumi T, Yamauchi K, M_ller T, Tang N, Hattori A, Hayakawa K, Suzuki N
  Toxics 12, 915 (2024).
• "Genes involved in osteogenic differentiation induced by low_intensity pulsed ultrasound in goldfish scales"
  Tabuchi Y, Kuroda K, Furusawa Y, Hirano T, Nagaoka R, Omura M, Hasegawa H, Hirayama J, Suzuki N
  Biomed Rep 22, 18 (2024).
• "Effects of exposure to the neonicotinoid pesticide clothianidin on mouse intestinal microbiota under unpredictable environmental stress"
  Yonoichi S, Hirano T（＊責任著者）, Hara Y, Ishida Y, Shoda A, Kimura M, Murata M, Mantani Y, Yokoyama T, Ikenaka Y, Hoshi N
  Toxicol Appl Pharmacol 482, 116795 (2024).
• "Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice"
  Yonoichi S, Hara Y, Ishida Y, Shoda A, Kimura M, Murata M, Nunobiki S, Ito M, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Yokoi Y, Ayabe T, Nakamura K, Hoshi N＊
  J Vet Med Sci 86, 3, 277-284 (2024).
• "Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis"
  Ishida Y, Yonoichi S, Hara Y, Shoda A, Kimura M, Murata M, Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Matsuo E, Ikenaka Y, Hoshi N＊
  J Vet Med Sci 86, 3, 333-339 (2024).
• "Quantification of the tissue distribution and accumulation of the neonicotinoid pesticide clothianidin and its metabolites in maternal and fetal mice"
  Hirano T（＊責任著者）, Ohno S, Ikenaka Y, Onaru K, Kubo S, Miyata Y, Maeda M, Mantani Y, Yokoyama T, Nimako C, Yohannes YB, Nakayama SMM, Ishizuka M, Hoshi N
  Toxicol Appl Pharmacol 484, 116847 (2024).
• "Role of brain monoamines in acetamiprid-induced anxiety-like behavior"
  Hirai A, Toda C, Yohannes YB, Collins N, Tamba M, Nomiyama K, Eguchi A, Hoshi N, Hirano T, Nakayama SMM, Ishizuka M, Ikenaka Y＊
  Toxicology 505, 153839 (2024).
• "No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum"
  Hara Y, Shoda A, Yonoichi S, Ishida Y, Murata M, Kimura M, Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 86, 3, 340-348 (2024).

学会発表

• "無毒性量（NOAEL）に潜む農薬類による高次脳機能撹乱と発達神経毒性"
  平野哲史
  金沢大学 日本内分泌撹乱物質学会第26回研究発表会；2024 Dec 6；東京 (2024).

  招待講演
• "フィプロニル代謝物が誘導するミクログリアの活性化とニューロンとの相互作用の撹乱機序の解析"
  平野哲史，池中良徳，星　信彦，田渕圭章
  日本内分泌撹乱物質学会第26回研究発表会；2024 Dec 6-7；東京 (2024).
• "Mechanisms of disturbance of microglia-neuron interactions induced by environmental chemical-induced neuroinflammation"
  Hirano T, Hoshi N, Ikenaka Y, Tabuchi Y
  8th International Chemical Hazard Symposium；2024 Oct 24; Sapporo (2024).
• "Epigenomic Toxicity and Transgenerational Effects in Pesticides"
  Hoshi N, Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y
  8th International Chemical Hazard Symposium；2024 Oct 24-25；Sapporo (2024).
• "Developmental neurotoxicity of fetal and neonatal exposure to the phenylpyrazole pesticide fipronil in mice"
  Yoshimoto A, Ito M, Nunobiki S, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  8th International Chemical Hazard Symposium；2024 Oct 24-25；Sapporo (2024).
• "Paternal Clothianidin Exposure Alters Sperm miRNA Profiles in Mice and Affects Behavior in Male Offspring"
  Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  8th International Chemical Hazard Symposium；2024 Oct 24-25；Sapporo (2024).
• "Transgenerational Effects on Maternal Behavior Due to Exposure to a No-observed-adverse-effect-level (NOAEL) dose of Neonicotinoid Pesticide Clothianidin"
  Nunobiki S, Yoshimoto A, Ito M, Mantani Y, Morishita R, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  8th International Chemical Hazard Symposium；2024 Oct 24-25；Sapporo (2024).
• "農薬類が哺乳類の中枢神経系に及ぼす未知の神経毒性メカニズムの探索"
  平野哲史
  日本衛生学会若手研究者夏の集い2024；2024 Aug 19；東京 (2024).
• "フィプロニル代謝物が引き起こすミクログリア－ニューロン間相互作用の撹乱メカニズムの解明"
  平野哲史，池中良徳，星　信彦，田渕圭章
  第51回日本毒性学会学術年会；2024 Jul 3-5；福岡 (2024).

2023年

学術論文

• "Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice"
  Shoda A, Nishi M, Murata M, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N＊
  Toxicol Lett 373, 33-40 (2023).
• "Developmental stage-specific exposure and neurotoxicity evaluation of low-dose clothianidin during neuronal circuit formation"
  Shoda A, Murata M, Kimura M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 85, 4, 486-496 (2023).
• "Transgenerational effects of developmental neurotoxicity induced by exposure to a no-observed-adverse-effect level (NOAEL) of neonicotinoid pesticide clothianidin"
  Shoda A, Murata M, Kimura M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N＊
  J Vet Med Sci 85, 9, 1023-1029 (2023).
• "Next-generation effects of fetal and lactational exposure to the neonicotinoid pesticide clothianidin on the immune system and gut microbiota"
  Murata M, Shoda A, Kimura M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Matsuo E, Hirano T, Hoshi N＊
  J Vet Med Sci 85, 4, 434-442 (2023).
• "Neurotoxicity and behavioral disorders induced in mice by acute exposure to the diamide insecticide chlorantraniliprole"
  Kimura M, Shoda A, Murata M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N＊
  J Vet Med Sci 85, 4, 497-506 (2023).
• "An adverse outcome pathway-based approach to assess the neurotoxicity by combined exposure to current-use pesticides"
  Hirano T（＊責任著者）, Ikenaka Y, Nomiyama K, Honda M, Suzuki N, Hoshi N, Tabuchi Y
  Toxicology 500, 153687 (2023).

学会発表

• "Challenges and issues in detecting disturbances of higher brain function caused by environmental chemicals"
  Hirano T
  7th International Chemical Hazard Symposium；2023 Dec 13-14; Matsuyama (2023).

  基調講演
• "Sperm miRNA expression changes and next generation effects due to paternal exposure to neonicotinoid pesticides"
  Ito M, Nunobiki S, Yoshimoto A, Hara Y, Ishida Y, Yonoichi S, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  7th International Chemical Hazard Symposium；2023 Dec 13-14; Matsuyama (2023).
• "Transgenerational effects of maternal behavior induced by exposure to neonicotinoid pesticide"
  Nunobiki S, Yoshimoto A, Ito M, Yonoichi S, Hara Y, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  7th International Chemical Hazard Symposium；2023 Dec 13-14; Matsuyama (2023).
• "Developmental neurotoxicity of fipronil"
  Yoshimoto A, Ito M, Nunobiki S, Hara Y, Ishida Y, Yonoichi S, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  7th International Chemical Hazard Symposium；2023 Dec 13-14; Matsuyama (2023).
• "ネオニコチノイド系農薬曝露による腸内細菌叢変動メカニズムに関する研究"
  世ノ一さくら，石田祐也，原悠佳子，伊藤槙子，布引沙利香，吉本彩乃，平野哲史，万谷洋平，横山俊史，池中良徳，綾部時芳，中村公則，星信彦
  第99回日本解剖学会近畿支部学術集会；2023 Nov 18．Kyoto (2023).
• "胎子授乳期ネオニコチノイド系農薬曝露が海馬記憶と小脳運動学習機能に及ぼす継世代影響"
  原悠佳子，世ノ一さくら，石田祐也，伊藤槙子，布引沙利香，吉本彩乃，万谷洋平，横山俊史，平野哲史，池中良徳，星信彦
  第166回日本獣医学会学術集会；2023年Sep 5-8；府中 (2023).
• "Assessment of combined neurotoxic effects of pesticides using adverse outcome pathway (AOP)-based approach"
  Hirano T, Ikenaka Y, Hoshi N, Tabuchi Y
  10th International Congress of Asian Society of Toxicology；2023 Jul 17-20; Taipei (2023).
• "フィプロニル代謝物が引き起こすミクログリアの活性化がエクソソームを介してニューロンに及ぼす影響"
  平野哲史，池中良徳，星　信彦，田渕圭章
  第50回日本毒性学会；2023 Jun 19-21；横浜 (2023).
• "フィプロニル代謝物によるミクログリアの活性化およびエクソソーム分泌を介したニューロンへの作用"
  平野哲史，池中良徳，星　信彦，田渕圭章
  第2回環境化学物質3学会合同大会；2023 May 30-Jun 2；徳島 (2023).
• "Effects of the diamide pesticide chlorantraniliprole on behavioral and neural activity in mice"
  Kimura M, Shoda A, Murata M, Hara Y, Yonoichi S, Ishida Y, MantaniY, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  6th International Chemical Hazard Symposium；2023 Jan 12-13; Sapporo (2023).
• "Transgenerational effects of the neonicotinoid clothianidin exposure during the fetal and lactational periods on the hippocampal spatial memory and motor learning of male mice"
  Hara Y, Yonoichi S, Ishida Y, Shoda A, Murata M, Kimura M, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  6th International Chemical Hazard Symposium；2023 Jan 12-13; Sapporo (2023).
• "Neonicotinoid pesticide clothianidin and environmental stress impact on gut microbiota in mice"
  Yonoichi S, Ishida Y, Hara Y, Kimura M, Shoda A, Murata M, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N
  6th International Chemical Hazard Symposium；2023 Jan 12-13; Sapporo (2023).

2022年

学術論文

• "Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy in vivo imaging"
  Nishi M, Sugio S, Hirano T, Kato D, Wake H, Shoda A, Murata M, Ikenaka Y, Tabuchi Y, Mantani Y, Yokoyama T, Hoshi N＊
  J Vet Med Sci 84, 4, 585-592 (2022).
• "Sex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice"
  Kubo S, Hirano T（＊責任著者）, Miyata Y, Ohno S, Onaru K, Ikenaka Y, Nakayama SMM, Ishizuka M, Mantani Y, Yokoyama T, Hoshi N
  Toxicol Appl Pharmacol 456, 116283 (2022).
• "Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides"
  Hirai A, Sugio S, Nimako C, Nakayama SMM, Kato K, Takahashi K, Arizono K, Hirano T, Hoshi N, Fujioka K, Taira K, Ishizuka M, Wake H, Ikenaka Y＊
  Sci Rep 12, 1, 5114 (2022).

学会発表

• "ネオニコチノイド系農薬が哺乳類に及ぼす神経行動学的影響評価とメカニズム解析"
  平野哲史
  金沢大学 環日本海域環境研究センター主催講演会「環境汚染物質に関する近年の課題と研究」；2022 Jun 17；金沢 (2022).

  招待講演
• "ジアミド系農薬がマウスの行動および神経活動に及ぼす影響評価"
  木村真子，正田明日香，村田　碧，原　悠佳子，世ノ一さくら，石田祐也，平野哲史，万谷洋平，横山俊史，池中良徳，星　信彦
  第150回関西実験動物研究会研究発表会；2022 Dec 16；神戸 (2022).
• "ジアミド系農薬がマウスの行動および神経活動に及ぼす影響について"
  木村真子，正田明日香，村田　碧，原　悠佳子，世ノ一さくら，石田祐也，平野哲史，万谷洋平，横山俊史，池中良徳，星　信彦
  第98 回日本解剖学会近畿支部学術集会；2022 Nov 26；高槻 (2022).
• "環境ストレス負荷下におけるネオニコチノイド系農薬曝露が腸内細菌叢に及ぼす影響"
  世ノ一さくら，石田祐也，原　悠佳子，木村真子，正田明日香，村田　碧，万谷洋平，横山俊史，平野哲史，池中良徳，星　信彦
  第165回日本獣医学会学術集会；2022 Sep 6-8；相模原 (2022).
• "胎子授乳期ネオニコチノイド系農薬曝露が海馬記憶と運動学習に及ぼす次世代影響"
  原　悠佳子，世ノ一さくら，石田祐也，正田明日香，村田　碧，木村真子，万谷洋平，横山俊史，平野哲史，池中良徳，星　信彦
  第165回日本獣医学会学術集会；2022 Sep 6-8；相模原 (2022).
• "神経毒性に関するAdverse Outcome Pathway (AOP) に基づいた農薬類の複合影響評価"
  平野哲史，池中良徳，星　信彦，田渕 圭章
  第49回日本毒性学会；2022 Jun 30-July 2；札幌 (2022).
• "神経毒性のAOPにおける共通Key Eventを指標とした農薬類の複合影響評価"
  平野哲史，池中良徳，星　信彦，田渕圭章
  環境化学物質 3 学会合同大会（第 30 回環境化学討論会，第 26 回日本環境毒性学会研究発表会，第 24 回環境ホルモン学会研究発表会）；2022 Jun 14-16；富山 (2022).
• "Neurotoxic mechanisms of a pyrethroid pesticide deltamethrin induced by imbalance of proteolytic system"
  Hirano T, Hoshi N, Ikenaka Y, Tabuchi Y
  5th International Chemical Hazard Symposium；2022 Feb 3; Sapporo. (online) (2022).
• "Molecular mechanism of neurotoxicity of a pyrethroid pesticide deltamethrin via dysfunction in proteolytic systems"
  Hirano T, Ikenaka Y, Hoshi N, Tabuchi Y
  61th SOT annual meeting；2022 Mar 27-31; San Diego. (online) (2022).

2021年

学術論文

• "Genetic response to low_intensity ultrasound on mouse ST2 bone marrow stromal cells"
  Tabuchi Y＊, Hasegawa H, Suzuki N, Furusawa Y, Hirano T, Nagaoka R, Hirayama J, Hoshi N, Mochizuki T
  Mol Med Rep 23, 3 (2021).
• "The effects of fipronil on emotional and cognitive behaviors in mammals"
  Suzuki T, Hirai A, Khidkhan K, Nimako C, Ichise T, Takeda K, Mizukawa H, Nakayama SMM, Nomiyama K, Hoshi N, Maeda M, Hirano T, Sasaoka K, Sasaki N, Takiguchi M, Ishizuka M, Ikenaka Y＊
  Pestic Biochem Physiol 175, 104847 (2021).
• "Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice"
  Nimako C, Ikenaka Y, Okamatsu-Ogura Y, Bariuan JV, Kobayashi A, Yamazaki R, Taira K, Hoshi N, Hirano T, Nakayama SMM, Ishizuka M＊
  J Vet Med Sci 83, 3, 487-500 (2021).
• "Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice"
  Maeda M, Yokoyama T, Kitauchi S, Hirano T, Mantani Y, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 83, 2, 344-348 (2021).
• "Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice"
  Maeda M, Kitauchi S, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Yokoyama T, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 83, 3, 542-548 (2021).
• "Effects of in utero and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice"
  Kitauchi S, Maeda M, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Yokoyama T, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 83, 4, 746-753 (2021).
• "Bioinformatics analysis of the microRNA-mRNA network in sebaceous gland carcinoma of the eyelid"
  Hirano T, Yunoki T, Furusawa Y, Tabuchi Y＊, Hayashi A
  Mol Med Rep 23, 1 (2021).
• "Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition"
  Hirano T（＊責任著者）, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y
  Toxicol Appl Pharmacol 430, 115723 (2021).
• "Aging-related changes in the sensitivity of behavioral effects of the neonicotinoid pesticide clothianidin in male mice"
  Hirano T（＊責任著者）, Miyata Y, Kubo S, Ohno S, Onaru K, Maeda M, Kitauchi S, Nishi M, Tabuchi Y, Ikenaka Y, Ichise T, Nakayama SMM, Ishizuka M, Arizono K, Takahashi K, Kato K, Mantani Y, Yokoyama T, Hoshi N
  Toxicol Lett 342, 95-103 (2021).

学会発表

• "タンパク質分解系の不均衡状態を介したピレスロイド系農薬による神経毒性の発現機序"
  平野哲史，池中良徳，星　信彦，田渕圭章
  環境ホルモン学会第23回研究発表会；2021 Sep 12-13；札幌 (2021).
• "低用量クロチアニジンの神経回路形成期におけるステージ別曝露と発達神経毒性評価"
  正田明日香，村田　碧，西　美咲，平野哲史，万谷洋平，横山俊史，池中良徳，星　信彦
  環境ホルモン学会第23回研究発表会；2021 Sep 12-13；札幌 (2021).
• "ネオニコチノイド系農薬クロチアニジンの胎子・授乳期曝露による次世代マウスの免疫系および腸内細菌叢の変化"
  村田　碧，西　美咲，正田明日香，池中良徳，佐伯圭一，松尾栄子，平野哲史，万谷洋平，横山俊史，星　信彦
  環境ホルモン学会第23回研究発表会；2021 Sep 12-13；札幌 (2021).
• "Imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition underlies neurotoxicity of pyrethroid pesticide deltamethrin"
  Hirano T, Ikenaka Y, Hoshi N, Tabuchi Y
  フォーラム2021：衛生薬学・環境トキシコロジー；2021 Sep 10-11；船橋 (2021).
• "神経回路形成期におけるステージ別ネオニコチノイド系農薬曝露と発達神経毒性評価"
  正田明日香，村田　碧，西　美咲，万谷洋平，横山俊史，池中良徳，平野哲史，星　信彦
  第164回日本獣医学会学術集会；2021 Sep 7-13；江別 (2021).
• "ネオニコチノイド系農薬クロチアニジンの胎子・授乳期曝露が次世代マウスの免疫系および腸内細菌叢に及ぼす影響"
  村田　碧，西　美咲，正田明日香，佐伯圭一，松尾栄子，万谷洋平，横山俊史，平野哲史，池中良徳，星　信彦
  第164回日本獣医学会学術集会；2021 Sep 7-13；江別 (2021).
• "ネオニコチノイド系農薬クロチアニジンのマウス母乳中移行量に関する定量的評価"
  正田明日香，村田　碧，西　美咲，平野哲史，万谷洋平，横山俊史，池中良徳，星　信彦
  第61回日本先天異常学会学術集会；2021 Aug 7-8；東京 (2021).
• "ネオニコチノイド系農薬クロチアニジンが次世代マウスの免疫系および腸内細菌叢に及ぼす影響"
  村田　碧，西　美咲，正田明日香，池中良徳，佐伯圭一，松尾栄子，平野哲史，万谷洋平，横山俊史，星　信彦
  第61回日本先天異常学会学術集会；2021 Aug 7-8；東京 (2021).
• "Neurobehavioral and neurofunctional effects of a neonicotinoid pesticide clothianidin on mammalian nervous system"
  Hirano T, Hoshi N, Ikenaka Y, Tabuchi Y
  4th International Chemical hazard symposium and 4th Symposium of Japan Society for Environmental Chemistry；2021 Mar 3; Hokkaido (2021).
• "Transgenerational inheritance effects and the adverse outcome pathway (AOP) of the exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin in the reproductive organs of female mice"
  Kitauchi S, Maeda M, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Yokoyama T, Tabuchi Y, Hoshi N
  4th International Chemical hazard symposium and 4th Symposium of Japan Society for Environmental Chemistry；2021 Mar 3; Hokkaido (2021).
• "Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in the next generation of male mice"
  Maeda M, Kitauchi S, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Tabuchi Y, Yokoyama T, Hoshi N
  4th International Chemical hazard symposium and 4th Symposium of Japan Society for Environmental Chemistry；2021 Mar 3; Hokkaido (2021).

2020年

学術論文

• "CDKN2A, CDK1, and CCNE1 overexpression in sebaceous gland carcinoma of eyelid"
  Yunoki T＊, Hirano T, Tabuchi Y, Furusawa Y, Torigoe M, Nakajima T, Imura J, Hayashi A
  Int Ophthalmol 40, 2, 343-350 (2020).
• "Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice"
  Takada T, Yoneda N, Hirano T, Onaru K, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Nimako C, Ishizuka M, Ikenaka Y, Hoshi N＊
  J Vet Med Sci 82, 3, 350-359 (2020).
• "HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC_3 cells"
  Tabuchi Y＊, Maekawa K, Torigoe M, Furusawa Y, Hirano T, Minagawa S, Yunoki T, Hayashi A
  Int J Mol Med 46, 1, 58-66 (2020).
• "Low-intensity pulsed ultrasound promotes the expression of immediate-early genes in mouse ST2 bone marrow stromal cells"
  Tabuchi Y＊, Hasegawa H, Suzuki N, Furusawa Y, Hirano T, Nagaoka R, Takeuchi SI, Shiiba M, Mochizuki T
  J Med Ultrason 47, 2, 193-201 (2020).
• "Immunotoxicity evaluation by subchronic oral administration of clothianidin in Sprague-Dawley rats"
  Onaru K, Ohno S, Kubo S, Nakanishi S, Hirano T, Mantani Y, Yokoyama T, Hoshi N＊
  J Vet Med Sci 82, 3, 360-372 (2020).
• "Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice"
  Ohno S, Ikenaka Y, Onaru K, Kubo S, Sakata N, Hirano T, Mantani Y, Yokoyama T, Takahashi K, Kato K, Arizono K, Ichise T, Nakayama SMM, Ishizuka M, Hoshi N＊
  Toxicol Lett 322, 32-38 (2020).
• "Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads"
  Hasegawa C, Yokoyama T＊, Umemura Y, Kawanishi K, Miura Y, Takada N, Ohno S, Onaru K, Omotehara T, Hirano T, Mantani Y, Miki T, Hoshi N
  J Vet Med Sci 82, 4, 414-421 (2020).

学会発表

• "極微量ネオニコチノイド系農薬がマウスの継世代雌性生殖器に及ぼす影響"
  北内佐也可，前田瑞稀，平野哲史，万谷洋平，横山俊史，星 信彦
  第163回日本獣医学会学術集会；2020 Sep 8-10，山口 (2020).
• "無毒性量ネオニコチノイド系農薬が次世代のマウス雌性生殖機能に及ぼす影響"
  北内佐也可，前田瑞稀，平野哲史，万谷洋平，横山俊史，星 信彦
  第60回日本先天異常学会学術集会；2020 Jul 10-12；神戸 (2020).
• "無毒性量の浸透性農薬のマウス胎子・授乳期曝露による神経行動学的影響"
  前田瑞稀，北内佐也加，平野哲史，万谷洋平，横山俊史，星 信彦
  第60回日本先天異常学会；2020 Jul 10-12；神戸 (2020).

2019年

学術論文

• "Genetic differences between C57BL/6 substrains affect the process of testis differentiation in YPOS mice"
  Yokoyama T＊, Miura Y, Yamamoto A, Hasegawa C, Kawanishi K, Takada N, Omotehara T, Hirano T, Mantani Y, Miki T, Hoshi N
  J Vet Med Sci 81, 4, 608-611 (2019).
• "Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells"
  Hirano T（＊責任著者）, Minagawa S, Furusawa Y, Yunoki T, Ikenaka Y, Yokoyama T, Hoshi N, Tabuchi Y
  Toxicol Appl Pharmacol 383, 114777 (2019).

学会発表

• "クロチアニジンの亜急性摂取はラット腸内細菌叢を変化させる"
  大成果乃子，大野周嗣，久保静花，中西怜稀，平野哲史，万谷洋平，横山俊史，星　信彦
  第22回環境ホルモン学会研究発表会；2019 Dec 12-13；東京 (2019).
• "低用量クロチアニジンによるマウスの物体認識・空間学習記憶障害とその性差"
  大野周嗣，大成果乃子，久保静花，平野哲史，万谷洋平，横山俊史，石塚真由美，池中良徳，星　信彦
  第22回環境ホルモン学会研究発表会；2019 Dec 12-13；東京 (2019).
• "低用量クロチアニジンによる情動変容への加齢の影響評価"
  久保静花，宮田結佳，大成果乃子，大野周嗣，平野哲史，万谷洋平，横山俊史，星　信彦
  第22回環境ホルモン学会研究発表会；2019 Dec 12-13；東京 (2019).
• "クロチアニジンおよびその代謝産物の母子間移行における組織分布・蓄積性の定量的解明"
  宮田結佳，久保静花，大野周嗣，大成果乃子，前田瑞稀，中西怜稀，平野哲史，万谷洋平，横山俊史，石塚真由美，池中良徳，星　信彦
  第22回環境ホルモン学会研究発表会；2019 Dec 12-13；東京 (2019).
• "低用量クロチアニジンの胎子・授乳期曝露による神経行動学的影響"
  前田瑞稀，北内佐也可，宮田結佳，久保静花，平野哲史，万谷洋平，横山俊史，星　信彦
  第22回環境ホルモン学会研究発表会；2019 Dec 12-13；東京 (2019).
• "ネオニコチノイド系農薬クロチアニジンが次世代雌性生殖器に及ぼす影響"
  北内佐也可，前田瑞稀，久保静花，大成果乃子，宮田結佳，平野哲史，万谷洋平，横山俊史，星　信彦
  第22回環境ホルモン学会研究発表会；2019 Dec 12-13；東京 (2019).
• "GABA攪乱物質フィプロニルがマウスの情動行動に及ぼす影響"
  前田瑞稀，大成果乃子，大野周嗣，久保静花，杉田晄佑，宮田結佳，北内佐也加，西　美咲，高田　匡，平野哲史，万谷洋平，横山俊史，池中良徳，星　信彦
  第162回日本獣医学会；2019 Sep 10-12；つくば (2019).
• "ネオニコチノイド系農薬クロチアニジンが哺乳類に及ぼす神経行動学的影響とそのメカニズム"
  平野哲史，大成果乃子，大野周嗣，久保静花，杉田晄佑，宮田結佳，前田瑞稀，北内佐也可，西　美咲，横山俊史，田渕 圭章，星　信彦
  第2回極みプロジェクトシンポジウム・第6回イメージング数理研究会；2019 Sep 2；神戸 (2019).
• "ネオニコチノイド系農薬がヒト神経芽細胞腫に及ぼすシグナル毒性的影響に関するメカニズム解析"
  平野哲史，皆川沙月，古澤之裕，柚木達也，池中良徳，横山俊史，星　信彦，田渕圭章
  第46回日本毒性学会学術年会；2019 Jun 26-28；徳島 (2019).
• "In vivo and in vitro effects of neonicotinoid pesticide, clothianidin on mammal nervous function"
  Hirano T＊, Minagawa S, Furusawa Y, Yunoki T, Yokoyama T, Hoshi N, Tabuchi Y
  IUTOX 15th International Congress of Toxicology；2019 Jul 15-18; Honolulu, Hawaii (2019).
• "Adverse effects on cognitive-emotional behavior and immune system function in experimental animals administered a NOAEL-dose of neonicotinoids"
  Hoshi N＊, Hirano T, Ikenaka Y, Ohno S, Onaru K, Kubo S, Maeda M, Miyata Y, Sugita K, Ishizuka M, Mantani Y, Yokoyama T
  International Chemical hazard Symposium in Hokkaido；2019 Mar 20; Sapporo (2019).

2018年

学術論文

• "Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling"
  Yunoki T＊, Tabuchi Y, Hirano T, Miwa S, Imura J, Hayashi A
  Oncol Lett 16, 5, 6729-6734 (2018).
• "Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice"
  Yoneda N, Takada T, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 80, 4, 634-637 (2018).
• "Identification of reference genes for quantitative PCR analyses in developing mouse gonads"
  Yokoyama T＊, Omotehara T, Hirano T, Kubota N, Yanai S, Hasegawa C, Takada T, Mantani Y, Hoshi N
  J Vet Med Sci 80, 10, 1534-1539 (2018).
• "The mechanisms underlying the effects of AMH on M_llerian duct regression in male mice"
  Yamamoto A, Omotehara T, Miura Y, Takada T, Yoneda N, Hirano T, Mantani Y, Kitagawa H, Yokoyama T, Hoshi N＊
  J Vet Med Sci 80, 4, 557-567 (2018).
• "Verification of the causal relationship between subchronic exposures to dinotefuran and depression-related phenotype in juvenile mice"
  Takada T, Yoneda N, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N＊
  J Vet Med Sci 80, 4, 720-724 (2018).
• "NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with human-audible vocalizations in male mice in a novel environment"
  Hirano T, Yanai S, Takada T, Yoneda N, Omotehara T, Kubota N, Minami K, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  Toxicol Lett 282, 57-63 (2018).
• "Identification of genes and genetic networks associated with BAG3_dependent cell proliferation and cell survival in human cervical cancer HeLa cells"
  Furusawa Y＊, Yunoki T, Hirano T, Minagawa S, Izumi H, Mori H, Hayashi A, Tabuchi Y
  Mol Med Rep 18, 4, 4138-4146 (2018).

学会発表

• "ネオニコチノイド系農薬クロチアニジンはヒト神経芽細胞腫においてCa2+シグナルのかく乱を引き起こす"
  平野哲史，皆川沙月，古澤之裕，柚木達也，横山俊史，星　信彦，田渕圭章
  第21回環境ホルモン学会研究発表会；2018 Dec 15-16；東京 (2018).
• "母子間移行における浸透性農薬およびその代謝産物の定量的な解明"
  大野周嗣，大成果乃子，久保静花，坂田奈那美，平野哲史，万谷洋平，横山俊史，石塚真由美，池中良徳，星　信彦
  第21回環境ホルモン学会研究発表会；2018 Dec 15-16；東京 (2018).
• "無毒性量のネオニコチノイド系農薬曝露による行動影響の性差"
  久保静花，宮田結佳，大成果乃子，大野周嗣，高田　匡，平野哲史，横山俊史，星　信彦
  第21回環境ホルモン学会研究発表会；2018 Dec 15-16；東京 (2018).
• "ネオニコチノイド系農薬が老年動物に及ぼす影響"
  宮田結佳，久保静花，大野周嗣，前田瑞稀，荒井真也，中西怜稀，高田　匡，平野哲史，横山俊史，星　信彦
  第21回環境ホルモン学会研究発表会；2018 Dec 15-16；東京 (2018).
• "浸透性農薬とその代謝産物の胎子移行量の解明"
  大野周嗣、大成果乃子、久保静花、坂田奈那美、杉田晄佑、宮田結佳、高田　匡、平野哲史、万谷洋平、横山俊史、石塚真由美、池中良徳、星　信彦
  第161回日本獣医学会学術集会；2018 Sep 11-13；つくば (2018).
• "ネオニコチノイド系農薬が老齢動物に及ぼす影響"
  宮田結佳、大成果乃子、大野周嗣、久保静花、杉田晄佑、高田　匡、前田瑞稀、中西怜稀、平野哲史、万谷洋平、横山俊史、星　信彦
  第161回日本獣医学会学術集会；2018 Sep 11-13；つくば (2018).
• "ネオニコチノイド系農薬における哺乳動物への免疫毒性の検証"
  大成果乃子、大野周嗣、久保静花、中西怜稀、荒井真也、杉田晄佑、宮田結佳、高田　匡、前田瑞稀、平野哲史、万谷洋平、横山俊史、星　信彦
  第161回日本獣医学会学術集会；2018 Sep 11-13；つくば (2018).
• "浸透性農薬の行動影響の性差"
  久保静花、宮田結佳、大成果乃子、大野周嗣、杉田晄佑、前田瑞稀、高田　匡、平野哲史、万谷洋平、横山俊史、星　信彦
  第161回日本獣医学会学術集会；2018 Sep 11-13；つくば (2018).

2017年

学術論文

• "Prenatal and early postnatal NOAEL-dose clothianidin exposure leads to a reduction of germ cells in juvenile male mice"
  Yanai S, Hirano T, Omotehara T, Takada T, Yoneda N, Kubota N, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 79, 7, 1196-1203 (2017).
• "Contribution of the coelomic epithelial cells specific to the left testis in the chicken embryo"
  Omotehara T, Minami K, Mantani Y, Umemura Y, Nishida M, Hirano T, Yoshioka H, Kitagawa H, Yokoyama T, Hoshi N＊
  Dev Dyn 246, 2, 148-156 (2017).

2016年

学術論文

• "Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XYPOS mice"
  Umemura Y, Miyamoto R, Hashimoto R, Kinoshita K, Omotehara T, Nagahara D, Hirano T, Kubota N, Minami K, Yanai S, Masuda N, Yuasa H, Mantani Y, Matsuo E, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 77, 12, 1587-1598 (2016).

2015年

学術論文

• "Immunohistochemical analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity on the developmental dentate gyrus and hippocampal fimbria in fetal mice"
  Kobayashi Y, Hirano T, Omotehara T, Hashimoto R, Umemura Y, Yuasa H, Masuda N, Kubota N, Minami K, Yanai S, Ishihara-Sugano M, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 77, 11, 1355-1361 (2015).
• "The combined effect of clothianidin and environmental stress on the behavioral and reproductive function in male mice"
  Hirano T, Yanai S, Omotehara T, Hashimoto R, Umemura Y, Kubota N, Minami K, Nagahara D, Matsuo E, Aihara Y, Shinohara R, Furuyashiki T, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 77, 10, 1207-1215 (2015).

2014年

学術論文

• "Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing gonads and Mullerian ducts"
  Omotehara T, Smith CA, Mantani Y, Kobayashi Y, Tatsumi A, Nagahara D, Hashimoto R, Hirano T, Umemura Y, Yokoyama T, Kitagawa H, Hoshi N＊
  Poult Sci 93, 4, 953-958 (2014).
• "Insight into the mechanism of reproductive dysfunction caused by neonicotinoid pesticides"
  Hoshi N＊, Hirano T, Omotehara T, Tokumoto J, Umemura Y, Mantani Y, Tanida T, Warita K, Tabuchi Y, Yokoyama T, Kitagawa H
  Biol Pharm Bull 37, 9, 1439-1443 (2014).
• "Unpredictable chronic stress-induced reproductive suppression associated with the decrease of kisspeptin immunoreactivity in male mice"
  Hirano T, Kobayashi Y, Omotehara T, Tatsumi A, Hashimoto R, Umemura Y, Nagahara D, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N＊
  J Vet Med Sci 76, 9, 1201-1208 (2014).